HOW DOES IT WORK THE LIVER CLEANSE WORK?
The Liver
Every day, the liver must process an almost unbelievable amount of blood – at a rate of three
pints every minute. All the while, the liver performs over 500 physiologic functions, including
protein and glucose synthesis, carbohydrate metabolism, vitamin and mineral storage, synthesis of
clotting factors, urea formation, metabolism of medications, and the production of bile. The liver
also assists in hormonal regulation, blood glucose control, and other regulatory functions.
Harmful substances that have been neutralized by the liver are carried to the intestines and kidneys
for excretion. They are transported by bile, a greenish, watery solution that is synthesized, and
continuously being excreted, by the liver. Stored in the gallbladder, a small sac cupped in the under
surface of the liver, bile is also required for the digestion of dietary fats. However, in the case
of toxins, bile is primarily an early transporter of the toxic compounds to the intestines, where they
can be bound to fiber that helps transport them out of the body. Environmental toxins, including lipid
(fat) soluble toxins, are broken into water-soluble components by bile to be excreted through the
kidneys or colon.
Liver Detoxification
Detoxification refers to the process of excreting potentially harmful compounds that are both
generated by the body and acquired through exposure to the environment. In the body, toxins are
generated as by-products of cellular metabolic processes. Examples include dead and digested
bacteria, hydrogen peroxide, cellular debris, and carbon dioxide.
The Environmental Protection Agency has determined that the amount of environmental toxins in the air,
groundwater, and soil has increased significantly in the last 40 years. In fact, the use of pesticides
has doubled every ten years since 1945. Americans are increasingly exposed to heavy metals, pesticides,
fossil fuel emissions, sulfur oxides, hydrocarbons, and other harmful chemicals. The Environmental
Protection Agency reports that traces of toxic chemicals can now be found in nearly every American.
Herbal Liver Support
One of the major components in Complete Liver Cleanse is its milk thistle extract, standardized to
contain 80% silymarin, the plant’s most bioactive compound. Milk Thistle provides support, at a cellular
level, for healthy liver function. A patented delivery system, known as the Phytosome process,
provides superior absorption of the milk thistle extract.
Silymarin, a key compound found in milk thistle, is a mixture of flavonoids with a long history of
liver support. Silymarin supports the health of Kupffer cells, specialized liver cells responsible for
removing bacteria, old blood cells, and other foreign matter from the liver’s blood supply. Silymarin
scavenges free radicals (superoxide anion radical and nitric oxide) produced by activated Kupffer cells,
supports healthy leukotriene levels, and supports glutathione production that is used in detoxification.
Silymarin also supports the health of hepatocytes, highly versatile liver cells with unique physiologic
functions. Studies of silymarin have demonstrated that it supports the health of the hepatocyte outer
membrane, which is crucial to the liver’s detoxification processes. Silymarin also supports the healthy
regenerative ability of the liver through support of protein synthesis in the hepatocytes.
Phytosome Process
A special, patented proves known as Phytosome enhances the absorption of milk thistle in Complete
Liver Cleanse. The Phytosome process pairs herbal ingredients with phosphatidylcholine molecules.
Phosphatidylcholine is a naturally occurring substance found in soybeans, egg yolks, and some vegetables.
In the body, phosphatidylcholine is an important building block of cell membranes.
When milk thistle (or other herbs) are bound with phosphatidylcholine, the phosphatidylcholine
molecule facilitates absorption through the intestines into the bloodstream. Research has shown
increased blood and serum levels for phytosome herbs in comparison to the individual herb alone.
To test whether binding an herb with phosphatidylcholine increased its bioavailability, researchers
gave volunteers identical amounts of either milk thistle alone, or milk thistle phytosome. The researchers
then took blood sample from the participants and measured the level of silybin (a key compound in milk
thistle). The measurements showed that silybin levels in participants taking the phytosome form of milk
thistle were higher, and that silybin was detected for a longer time, than those who took milk thistle
without the phytosome delivery system.
Other Herbal Liver Supportive Ingredients
Herbal extracts are often at their best when they are working synergistically – that is, when different
constituents of each plant work together and support each other. Complete Liver Cleanse contains a variety
of herbal extracts that have noted benefits for supporting the body’s healthy bile flow and free-radical
scavenging effects. These ingredients provide a wide spectrum of liver supportive benefits. For instance,
dandelion root extract supports healthy bile flow from the gallbladder.
Burdock Root:
Burdock is originally native to Europe and Asia, but was introduced to North America, probably during
colonial times. The plant is commonly found in the northern United States, and is very recognizable, with
large, heart-shaped leaves. It has a long history of traditional use for gastrointestinal support.
Burdock root (Arctium lappa) supports the natural physiologic processes of organs involved in detoxification
and elimination: notably, the liver, kidneys, and intestines.
Boldo:
Bolodo (pemus boldus) is a small evergreen native to South America, but naturalized to southern
Europe. The leaves are considered the health supportive part of the plant. This herb has a long
history of use in Chile, and became known in Western countries in the late 19th century. In scientific
studies, boldo appears to have strong free-radical scavenging ability, mostly attributed to the catechin
and flavonoids content of its leaves. In a clinical study, boldo also appears to relax smooth muscle and
support intestinal transit time.
Artichoke Leaf extract specifically supports healthy bile production in the liver and healthy
gastrointestinal function in general. Research into artichoke’s gastrointestinal supportive properties
has included at least three clinical trials. Artichoke’s role in supporting healthy cholesterol levels
within normal limits has also been investigated.
Turmeric
Turmeric (Curcuma longa) is a perennial shrub native to southern Asia with a long history as both a food
ingredient and for health support. More recently, turmeric has been investigated for its support of healthy
bile secretion, and pancreatic and gastric function. In a scientific study, dietary curcuminoids derived
from turmeric supported healthy lipid metabolism and cholesterol levels already within normal limits.
Curcumin has also been shown in scientific studies to enhance the activity of glutathione S-transferase
- an enzyme responsible for linking glutathione (one of the body’s natural antioxidants) with toxins to
help remove them from the body. In this way, it provides additional support for healthy liver function.
Detoxification
Calcium d-glucarate:
The process of detoxification is the breakdown and excretion of substances that are no longer needed or
may be harmful to the body. One of the ways in which the body excretes hormones and toxins is by binding
them to glucuronic acid in the liver, and then excreting this compound in the bile.
However, this process can be disrupted by B-glucuronidase, an enzyme that is produced by intestinal bacteria.
This enzyme has the ability to break (uncouple) the chemical bond established by glucuronic acid. This action
releases the bound toxins, which are then reabsorbed into the body instead of being excreted.
Calcium D-Glucarate is the calcium salt of d-glucaric acid. It is found in both the human body, and in
some plant sources, including broccoli and oranges.
Calcium d0glucarate enhances the body’s detoxification systems by inhibiting the actions of beta-glucuronidase.
This helps decrease the portion of active compounds that could be hazardous to the body.
Phytosterols Cholesterol is a waxy, fat-like substance that is vital to fat digestion, cell structure,
nerve insulation and hormone production. Cholesterol comes from two sources: dietary or “exogenous” cholesterol
absorbed in the intestine, and “endogenous” cholesterol formed mostly by the liver and stored in the gallbladder.
Cholesterol occurs in two forms known as lipoproteins. Lipoproteins act as transports that carry fat s to
and from the cells. High-density lipoprotein (HDL) carries low lipid density cholesterol (LDL) away from arterial
walls and returns it to the bloodstream. LDL then travels back to the liver, which processes and eliminates it.
While high levels of HDL cholesterol is desirable, high amounts of LDL cholesterol is not supportive of
optimal health.
LDL-cholesterol is both synthesized in the body, or absorbed into the bloodstream through receptor sites
in the intestines. Think of these receptors as “parking spaces” for cholesterol. As it happens, the liver
can receive up to 500 mg per day of cholesterol from intestinal absorption. (It can also produce as much
as 1000 mg per day).
One way to help reduce the absorption of LDL cholesterol molecules it to occupy their “parking places” in
the intestines. Phytosterols in Liver Cleanse are essentially the “fat” of plants. They’re found in nuts,
corn and rice and are some of the “good” fats associated with the benefits of olive oil, flaxseed oil and
other healthy oils.
The structure of phytosterols is so similar to cholesterol that they fit perfectly in the specially-shaped
intestinal parking spaces that LDL-cholesterol would normally occupy.
Taken with, or just before meals, phytosterols block the cholesterol receptor sites so that cholesterol
is excreted from the body rather than absorbed. Phytosterols also have the additional role of helping
promote healthy bile salt excretion in the intestines. The phytosterol blend in Complete Liver Cleanse
can help minimize the absorption of cholesterol from high-protein food sources, help retain healthy
cholesterol levels that are within normal limits, and move bile sat through the digestive system.
The Importance of Fiber and detoxification
Fiber plays a key role in the removal and excretion of intestinal toxins in detoxification. Only fibers
that can effectively bind toxins will be successful in eliminating these harmful substances. Due to the
unique benefits of individual fibers, the best binding, removal, and elimination effects are noted when
combining different fiber types. Complete Liver Cleanse contains a combination of oat beta-glucan and
konjac fiber that has been shown in scientific studies to bind to bile salts.
Dietary fibers are complex mixtures of cellulose, hemicellulose, pectin, mucilage, and gums, which are
resistant to digestive fluids or enzymes – that is, they aren’t absorbed into the bloodstream. So, while
fiber itself doesn’t necessarily provide nutrients, it does promote laxation and modulate gastric and
intestinal physiology. Intestinal flora that normally reside within the colon utilize fiber as a medium
for microbial fermentation, resulting in the synthesis of the vitamins, vitamin K and biotin, and the
formation of short chain fatty acids, or SCFA. SCFA have a simple, but important job: to be absorbed by
the colon mucosa, increasing fecal matter bulk and providing energy. Fiber has been demonstrated in
numerous clinical studies to provide support of gastrointestinal, cardiovascular, immune, and
endocrine function health.
Complete Liver Cleanse also features two unique fibers to promote detoxification – konjac and oat beta-glucan.
Konjac:
Konjac, (Amorphophallus Konjac) is a tuber native to Asia, rich in glucomannan polysaccharide. This
viscous material is made into a jelly, noodles and other foods. It has been used in Japan for at least
a thousand years.
As a fiber, konjac has shown positive results maintaining healthy cholesterol levels within normal
limits in clinical studies. This beneficial effect is due to konjac’s ability to boost excretion of bile acid.
Oat beta-glucan:
Oat beta-glucan has been a widely studied fiber source for supporting healthy cholesterol levels within normal
limits. In a randomized clinical study, oat beta-glucan showed support of healthy HDL/LDL ratios already within
normal limits in individuals over a three week trial.
Closely linked to cholesterol, oat beta-glucan has also been studied for its support of healthy bile
excretion. Fiber has benefits beyond maintaining healthy cholesterol levels already within normal limits.
It also contributes to healthy blood sugar levels already within normal limits. In a double-blind,
clinical study, the oat beta-glucan fiber used in Liver Cleanse was shown to have 4 times higher viscosity
than another high concentrate beta-glucan fiber.
Viscosity – the resistance to flow – is an important factor in beta-glucan, and all fiber. Water, for instance,
would have a low viscosity, because it provides very little resistance to movement. Fiber, on the other hand,
should have a higher viscosity in order to maximize its transit time through the GI tract, providing a gentle
“scrubbing” on the intestinal walls. Therefore, the higher the viscosity, the greater the potential benefit.
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